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Table 1 Comparison of ALDEx and ALDEx2

From: Unifying the analysis of high-throughput sequencing datasets: characterizing RNA-seq, 16S rRNA gene sequencing and selective growth experiments by compositional data analysis

Property ALDEx ALDEx2
Significance tests Effect size and ad hoc Welch’s t or Wilcoxon
Multiple test No Benjamini–Hochberg
correction   
Minimum dataset Two samples per Three samples per
  group group
Maximum dataset 3×3×5, 000 >300×300×20, 000
  2×2×20, 000  
  1. Dataset: samples in A × samples in B × number of features.