Figure 4

Posterior distribution and composition of microbial assemblages with respect to “normal” and “elevated” Nugent scores in asymptomatic human females. Distributions were inferred from the vaginal microbiomes of 32 individuals collected over a 16-week period [26]. (A) Mixing probabilities for the assemblages comprising 95% of the posterior distribution for “normal” and “elevated” Nugent scores. “Normal” was defined by a Nugent score of 0 to 3, and 47 assemblages were responsible for 95% of their posterior distribution. “Elevated” was defined by a Nugent score >4, and 12 assemblages were responsible for 95% of their posterior distribution. As five assemblages were shared between these two distributions, there are a total of 54 assemblages in this plot. (B) Relative magnitude of the mixing probabilities of 27 OTUs (identity is indicated along the x-axis of part (C) marginalized over the 54 assemblages in part (A). Note that 14 OTUs accounted for 95% of the posterior density (PD) of the “normal” Nugent score category and 19 OTUs accounted for 95% of the PD of the “elevated” Nugent score category. As six OTUs were shared between these two distributions, there are mixing probabilities for a total of 27 unique OTUs in this plot. (C) Empirical relative abundance of the 27 OTUs in the 484 training samples. OTU identity is given along the x-axis. Each row represents an individual sample.