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Fig. 7 | Microbiome

Fig. 7

From: Type 2 immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis

Fig. 7

Proposed model for the immune regulatory network that connects host, parasitic nematode, and SFB microbiota during N. brasiliensis infection in mice. We showed that SFB-colonized mice reduce SFB and expression of IL-17 upon infection with N. brasiliensis or induction with exogenous IL-25 in a way that is dependent on STAT6 activation by IL-13 and possibly modulation of intestinal AMP and mucin expression. This is consistent with a model in which the host type 2 response to parasite infection leads to SFB depletion with the net result of reduced intestinal IL-17 expression

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Microbiome

ISSN: 2049-2618

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