Fig. 7

MRSA colonization is type I interferon-dependent. a Wild type (WT) C57Bl/6 mice, type I IFN receptor knockout (IFNAR KO), and type II IFN receptor knockout mice (IFNGR KO) underwent intranasal instillation of MRSA (6.7 × 10⁷ CFU). Twenty-four hours later, nasal lavage was performed using 200 μl of sterile saline for enumeration of CFU. b wild type, IFNAR, and IFNGR knockout mice were administered intranasal poly I:C (50 mcg) daily for 3 days, followed by i.n. MRSA (6.7 × 10⁷ CFU). Twenty-four hours later, nasal lavage was performed for enumeration of CFU. (**adjusted p < 0.01 by Kruskal-Wallis ANOVA with Dunn correction for multiple comparisons)