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Fig. 3 | Microbiome

Fig. 3

From: Colitis susceptibility in p47phox−/− mice is mediated by the microbiome

Fig. 3

Increased DSS colitis susceptibility in p47phox−/− mice is not reversed by restoration of NOX2-mediated ROS production. BM transplantation was performed in 7-week-old age- and gender- matched irradiated mice (B6Tac-CD45.1+ ➔ B6Tac-CD45.1+, p47phox−/− ➔ p47phox−/−, B6Tac-CD45.1+ ➔ p47phox−/−, p47phox−/− ➔ B6Tac-CD45.1+) prior to DSS colitis induction. Changes in body weight (a), disease activity index (b), and survival (c) were assessed (B6Tac-CD45.1+ ➔ B6Tac-CD45.1+ (n = 5); p47phox−/− ➔ p47phox−/− (n = 5); B6Tac-CD45.1+ ➔ p47phox−/− (n = 10); p47phox−/− ➔ B6Tac-CD45.1+ (n = 8); (p = 0.615)). d Colonic tissue sections were blindly scored for inflammation, depth of injury, and crypt damage on day 9

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