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Fig. 4 | Microbiome

Fig. 4

From: The microbiota in bronchoalveolar lavage from young children with chronic lung disease includes taxa present in both the oropharynx and nasopharynx

Fig. 4

Lavage microbiota shows similarity to both OP and NP. Principal coordinate analysis (PCoA) demonstrating relationships between the microbiota in different specimen types based on a Bray-Curtis similarity matrix derived from square root transformed OTU-level data. a The NP and OP microbiota were distinct, whereas Lavage-1 and Lavage-2 specimens were dispersed between the OP and NP data points. Red circles = NP swabs. Dark blue squares = OP swabs. Light blue triangles = Lavage-1. Mustard diamonds = Lavage-2. b Dispersion across the main axis (PCO1) reflected differences in the relative abundance of the dominant OTU. The PCoA is identical to that in part A of this figure but has been coloured to indicate the relative abundance of the dominant OTU. Dark blue triangles = dominant OTU at <50 % relative abundance. Light blue squares = dominant OTU at 50–80 % relative abundance. Red circles = dominant OTU at >80 % relative abundance. c A vector plot visualising directional effects of dominant OTUs (Table 2) in the different specimen types. Vectors show the Pearson rank correlation between each OTU and the PCO axes. The vectors are labelled to indicate the BLAST identification of dominant OTUs. The Mitis Group Streptococci vector indicates a single OTU that could not be identified to the species level. Mitis Group Streptococci include Streptococcus pneumoniae. Vectors are not shown for Porphyromonas, Terrahaemophilus, and Gemella OTUs as they overlapped with Neisseria, Prevotella and Haemophilus haemolyticus, respectively. Likewise, vectors are not shown for Granulicatella adiacens and Moraxella nonliquiefaciens as they overlapped with the Streptococcus mitis and Moraxella lincolnii vectors, respectively

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