Altered gut microbiota in Rett syndrome

Microbiome

Table 1 Permutational multivariate analysis of variance (PERMANOVA) tests of the bacterial gut microbiota on the unweighted and weighted UniFrac distances and the Bray-Curtis dissimilarity according to individuals’ health status and constipation

	Metric	F	R ²	p value*
HC (n = 29) vs RTT (n = 50)	Unweighted UniFrac	6.84	0.08	≤0.003
	Weighted UniFrac	15.6	0.16	≤0.003
	Bray-Curtis	6.94	0.08	≤0.003
HC (n = 29) vs RTT-C (n = 34)	Unweighted UniFrac	5.59	0.08	≤0.003
	Weighted UniFrac	12.1	0.16	≤0.003
	Bray-Curtis	5.39	0.08	≤0.003
HC (n = 29) vs RTT-NC (n = 14)	Unweighted UniFrac	5.27	0.11	≤0.003
	Weighted UniFrac	8.75	0.17	≤0.003
	Bray-Curtis	5.47	0.11	≤0.003
RTT-C (n = 34) vs RTT-NC (n = 14)	Unweighted UniFrac	1.31	0.02	0.180
	Weighted UniFrac	1.10	0.02	0.687
	Bray-Curtis	1.76	0.03	0.180

HC healthy controls, RTT-C constipated Rett syndrome subjects, RTT-NC non-constipated Rett syndrome subjects
*Bonferroni corrected p values

ISSN: 2049-2618