Fig. 2

Pathogen overgrowth can be separated from background diversity. Sequence contig feature plots (“entropy landscapes”), depicting at least one sample from every subject group. Each data point represents an assembled contig, with colors corresponding to genus level taxonomy annotations. The three axes show contig length (X-axis), contig sequence heterogeneity (entropy, Y-axis), and GC-content (Z-axis). a Magnified view of the plot of patient CF-00 without taxonomic annotation. b The same plot (CF-00) but with taxonomic annotation. c Representative plots of one subject from each group. Throughout, genera constituting less than 5% of the annotated fraction, as well as unannotated contigs are shown in gray color