Fig. 5

Relative abundance of butyryl-CoA transferase related genes in Sv129 and BL6 mice and pathways catalyzing conversion of acetyl-CoA to butyrate. a The relative abundance of butyryl-CoA transferase genes was higher in Sv129 than BL6 mice. Of note, HF feeding increased the relative abundance of butyryl-CoA transferase genes in both strains. Statistical differences were analyzed by unpaired Wilcoxon rank-sum test (with FDR correction). Statistically significant differences (P < 0.05) between groups are denoted with different letters (a, b, c, d) on the top of the graphic boxes. b The pathways catalyzing conversion of acetyl-CoA to butyrate comprise eight enzymatic reactions, and the numbers of the enzymes catalyzing these reactions in Sv129 and BL6 mice are marked in different colors, Sv129 in blue, and BL6 in red. The number of the enzymes included in this pathway module is markedly higher in Sv129 mice than in BL6 mice