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Table 2 Predictive selection model defined different bacterial composition in ME/CFS diagnostic groups

From: Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome

Diagnostic groups

Selected bacterial species

 

In-sample

Cross-Validation

AUC

AUC

ER (%)

FP (%)

FN (%)

ME/CFS (50) vs. control (50)

  [Firmicutes] Coprococcus catus

↓

0.831

0.684

36.72

40.00

33.43

  [Firmicutes] Pseudoflavonifractor capillosus

↑

  [Firmicutes] Dorea formicigenerans

↓

  [Firmicutes] Faecalibacterium prausnitzii

↓

  [Firmicutes] Coprococcus catus

↓

0.893

0.745

29.68

29.71

29.64

  [Firmicutes] Pseudoflavonifractor capillosus

↑

  [Firmicutes] Dorea formicigenerans

↓

  [Firmicutes] Faecalibacterium prausnitzii

↓

  [Firmicutes] Clostridium asparagiforme

↑

  [Proteobacteria] Sutterella wadsworthensis

↓

  [Bacteroidetes] Alistipes putredinis

↓

  [Firmicutes] Anaerotruncus colihominis

↑

ME/CFS + IBS (21) vs. control (50)

  [Firmicutes] Faecalibacterium cf

↓

0.771

0.571

33.09

18.57

69.38

  [Bacteroidetes] Bacteroides vulgatus

↑

  [Firmicutes] Faecalibacterium cf

↓

0.923

0.687

25.59

18.43

43.48

  [Bacteroidetes] Bacteroides vulgatus

↑

  [Firmicutes] Faecalibacterium prausnitzii

↓

  [Bacteroidetes] Alistipes putredinis

↓

  [Firmicutes] Coprococcus catus

↓

  [Firmicutes] Faecalibacterium cf

↓

1

0.791

24.31

18.28

39.40

  [Bacteroidetes] Bacteroides vulgatus

↑

  [Firmicutes] Faecalibacterium prausnitzii

↓

  [Bacteroidetes] Alistipes putredinis

↓

  [Firmicutes] Coprococcus catus

↓

  [Firmicutes] Anaerostipes caccae

↑

  [Firmicutes] Dorea formicigenerans

↓

  [Firmicutes] Anaerotruncus colihominis

↑

  [Firmicutes] Clostridium asparagiforme

↑

ME/CFS w/o IBS (29) vs. control (50)

  [Bacteroidetes] Bacteroides caccae

↓

0.775

0.589

40.67

25.29

66.30

  [Firmicutes] Pseudoflavonifractor capillosus

↑

  [Bacteroidetes] Bacteroides caccae

↓

0.948

0.754

28.41

21.07

40.65

  [Firmicutes] Pseudoflavonifractor capillosus

↑

  [Bacteroidetes] Parabacteroides distasonis

↓

  [Bacteroidetes] Bacteroides fragilis

↑

  [Bacteroidetes] Prevotella buccalis

↑

  [Bacteroidetes] Bacteroides xylanisolvens

↑

  [Firmicutes] Dorea formicigenerans

↓

ME/CFS w/o IBS (29) vs. ME/CFS + IBS (21)

  [Bacteroidetes] Bacteroides vulgatus

↓

0.913

0.604

37.61

29.30

50.08

  [Bacteroidetes] Prevotella buccalis

↑

  [Firmicutes] Ruminococcus lactaris

↑

  [Firmicutes] Eubacterium hallii

↑

  [Firmicutes] Anaerotruncus colihominis

↓

  [Firmicutes] Faecalibacterium cf

↑

  [Firmicutes] Clostridium methylpentosum

↑

  [Bacteroidetes] Bacteroides vulgatus

↓

0.956

0.604

41.51

27.32

62.80

  [Bacteroidetes] Prevotella buccalis

↑

  [Firmicutes] Ruminococcus lactaris

↑

  [Firmicutes] Eubacterium hallii

↑

  [Firmicutes] Anaerotruncus colihominis

↓

  [Firmicutes] Faecalibacterium cf

↑

  [Firmicutes] Clostridium methylpentosum

↑

  [Firmicutes] Faecalibacterium prausnitzii

↑

  [Proteobacteria] Klebsiella pneumoniae

↓

  [Bacteroidetes] Parabacteroides distasonis

↓

  [Bacteroidetes] Prevotella copri

↑

  1. The arrows represent the increased or decreased relative abundance of bacterial species in total ME/CFS, ME/CFS + IBS, ME/CFS w/o IBS (compared to controls). In the last comparison, the arrow represents changes in the ME/CFS without IBS group (compared to ME/CFS with IBS). ME/CFS myalgic encephalomyelitis/chronic fatigue syndrome, IBS irritable bowel syndrome, AUC area under the curve, ER error rate, FP false positive, FN false negative