Improved detection of gene-microbe interactions in the mouse skin microbiota using high-resolution QTL mapping of 16S rRNA transcripts

Table 3 List of potential candidate genes located in the defined confidence intervals

	Trait	Category	Chr	Immune-related genes	Genes related to skin biological processes
DNA	Deltaproteobacteria	Order	8	–	*Cdh13*
	Deltaproteobacteria	Order	9	Gclc	–
	Un.Bacteroidetes_OTU23	Species	9	Gclc, Fbxo9, Ick, Gsta4, Eef1a1	Gsta4, Gsta1, Gsta2, Cd109, Ddx43,Col12a1
	Bradyrhizobium_OTU8	Species	13	Trim38, Hfe, Btn1a1, Btn2a2	–
	Clostridium_XI_OTU29	Species	13	Trim38, Hfe, Btn1a1, Btn2a2, Cmah	Cmah
RNA	Acinetobacter_OTU51	Species	1	Cops5	Arfgef1
	Prevotellaceae	Family	1	ClK1	–
	Staphylococcus_OTU15	Species	3	Ppp3ca	–
	Streptococcus	Genus	10	Scyl2	Scyl2
	Prevotellaceae	Family	12	–	Apob
	Halomonas	Genus	13	Sox4	Prl, Sox4, Cdkal, E2f3
	Streptophyta	Genus	14	Mmp14, Psmb11, Cebpe, Il25, Psme1, Psme2, Irf9, Rnf31, Mdp1, Rabggta, Ripk3, Cma1, Mcpt1, Mcpt4, Mcpt8, Ctsg, Gzmd, Gzmn, Gzmf, Gzmc, Gmzb, Homez	Mmp14, Ltb4r2, Ltb4r1, Psme1, Mcpt1, Mcpt4, Psme2, Prmt5, Slc7a8, Cmtm5, Pck2, Rec8, Nedd8, Tgm1, Dhrs1, Ctsg, Gzme, Gmzb, *Atp12a, Tinf2*
	Flavobacteriales	Order	14	–	Pou4f1
	Un.Betaproteobacteria	Genus	15	–	*Nell2*
	Epsilonproteobacteria, Campylobacteraceae	Order, family	17	–	Pkdcc
	Serratia_OTU117	Species	18	–	Ppargc1b, Csnk1a1
	Un.Lachnospiraceae_OTU82	Species	19	Dock8	Dock8

Only genes whose functions are experimentally demonstrated to be related to immune response and/or to other skin biological processes are reported. Genes in bold indicate the presence of the peak SNP
Chr chromosome, Un unclassified

ISSN: 2049-2618