Fig. 1From: More than just a gut feeling: constraint-based genome-scale metabolic models for predicting functions of human intestinal microbesSimplified overview of the use of GEM to increase understanding of the metabolic interactions in the gut microbiome. Individual species require metabolites (squares) to grow. These metabolites can be predicted by GEMs, which results in medium and growth (rate) prediction (i, top). The possible solution the bacteria use to metabolize these metabolites can change under different conditions (ii, middle), which leads to altered interactions between bacteria (iii, bottom)Back to article page