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Fig. 1 | Microbiome

Fig. 1

From: Influence of the pneumococcal conjugate vaccines on the temporal variation of pneumococcal carriage and the nasal microbiota in healthy infants: a longitudinal analysis of a case–control study

Fig. 1

Pneumococcal carriage. Samples from the PCV7 era (blue, n = 355) were compared to samples from the PCV13 era (red, n = 408). Shown are the raw data (a, c) and the fitted data (b, d) using linear mixed effect (LME) models. The fixed effects were age, season, season of birth, symptoms of lower respiratory tract infection (LRTI), and vaccine era. The random effects were intercepts for the infants and by-infant random slopes for the effect of the vaccine era. Lines are based on a local polynomial regression fitting (loess function in R). Gray bands indicate the standard deviation (SD). a Pneumococcal carriage as measured by the lytA quantity (log transformed). b Fitted values of the lytA quantity using the LME model. There was no significant difference between the PCV7 and the PCV13 era (LME model; P = 0.12). c Number of samples positive for pneumococcal carriage as defined by >10 lytA copies. d Fitted values of the number of samples positive using the LME model. Significantly lower number of samples positive for lytA in the PCV13 as compared to the PCV7 era (LME model; P = 0.01)

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Microbiome

ISSN: 2049-2618

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