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Fig. 6 | Microbiome

Fig. 6

From: Influence of the pneumococcal conjugate vaccines on the temporal variation of pneumococcal carriage and the nasal microbiota in healthy infants: a longitudinal analysis of a case–control study

Fig. 6

Cluster stability of the bacterial core microbiota. Cluster stability was calculated by the Jensen–Shannon distance based on the cluster matrix as input. A lower Jensen–Shannon distance indicates a higher stability because fewer switches between clusters occur. a Indicated is the within-subject Jensen–Shannon distance for each infant. Infant numbers 1–20 were vaccinated with the PCV7 and infant numbers 21–41 with the PCV13. b The mean within-subject Jensen–Shannon distance between PCV7-vaccinated infants (n = 20) and PCV13-vaccinated infants (n = 21) was compared. There was a significantly lower mean Jensen–Shannon distance in the PCV13 era as compared to the PCV7 era (t test; P = 0.03).

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