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Fig. 4 | Microbiome

Fig. 4

From: Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins

Fig. 4

Interaction network between FusoSecretome candidate virulence proteins and preferentially targeted modules. a Candidate virulence proteins are depicted as green rectangular nodes labeled with respective gene symbol, whereas network modules as orange circles, whose size is proportional to the number of proteins belonging to each module and are labeled with the corresponding identifier. Edge width is proportional to the number of inferred interactions of a virulence protein with a given module. Network modules enriched in gut-related disease gene sets are labeled with symbols of different colors (i.e., light blue star: Crohn’s disease, CD; dark blue star: Inflammatory bowel disease, IBD; violet star: genes whose expression correlates with F. nucleatum abundance in colorectal cancer patients, FusoExpr; rose star: genes mutated in colorectal cancer, CRC-mutated; rose zig-zag arrow: dysregulated expression during colorectal cancer progression, CRC-dysregulated). b The protein Fap2 (FN1449) interacts with 9 proteins (nodes with a green border) of Module 9 and c the MORN2 domain containing protein (FN2118) interacts with 8 proteins in Module 89

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