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Table 4 List of the main candidate virulence proteins in the FusoSecretome

From: Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins

UniprotKB AC

Protein name

Gene symbol

Domains

Interacting domains

Interacting SLiMs

Q8RIM1

Fusobacterium outer membrane protein family

FN1554

Autotransportera

–

LIG_FHA_1, LIG_FHA_2, LIG_PP1b, LIG_SH2_SRCb, LIG_SH2_STAT5, LIG_SH3_3b, LIG_SUMO_SBM_1b, MOD_N-GLC_1b, TRG_ENDOCYTIC_2b

Q8RGK2

Hemolysin

FN0291

Fil_haemagg_2a

–

LIG_FHA_1, LIG_FHA_2, LIG_Rb_pABgroove_1b, LIG_SH2_GRB2, LIG_SH2_SRCb, LIG_SH2_STAT5, LIG_SUMO_SBM_1b, MOD_CK1_1, MOD_CK2_1b, MOD_GSK3_1, MOD_N-GLC_1b, MOD_PIKK_1, TRG_ENDOCYTIC_2b

Q8RGT9

Peptide methionine sulfoxide reductase MsrA

msrA

PMSR, SelR

PMSR, SelR

CLV_PCSK_PC1ET2_1, LIG_FHA_1, LIG_SH2_GRB2, LIG_SH2_SRCb, LIG_SH2_STAT5, MOD_Cter_Amidation, MOD_PIKK_1, TRG_ENDOCYTIC_2b

Q8RHB9

Hypothetical exported 24-amino acid repeat protein

FN2118

MORN_2

–

LIG_SH2_GRB2, LIG_SH2_SRCb

Q8R609

Pyruvate-flavodoxin oxidoreductase

FN1421

POR_N, POR, EKR, Fer4_7, TPP_enzyme_C

TPP_enzyme_C

LIG_CYCLIN_1b, LIG_SH2_GRB2, LIG_SH2_STAT5, LIG_SH3_3b, LIG_SUMO_SBM_1b, LIG_WW_Pin1_4, MOD_CK1_1, MOD_CK2_1b, MOD_GSK3_1, MOD_PIKK_1, MOD_ProDKin_1, TRG_ENDOCYTIC_2b

Q8RH03

Chaperone protein DnaJ

dnaJ

DnaJ, DnaJ_CXXCXGXG, CTDII

DnaJ, DnaJ_CXXCXGXG

CLV_NDR_NDR_1, CLV_PCSK_SKI1_1, LIG_CYCLIN_1b, LIG_FHA_2, LIG_SH2_STAT5, LIG_SH3_3b, LIG_SUMO_SBM_1b, LIG_TRAF2_1b, LIG_WW_Pin1_4, MOD_CK2_1b, MOD_PLK, MOD_ProDKin_1, TRG_ENDOCYTIC_2b

Q8R643

Pyruvate-flavodoxin oxidoreductase

FN1170

POR_N, POR, EKR, Fer4_7, TPP_enzyme_C

TPP_enzyme_C

LIG_BRCT_BRCA1_1, LIG_SH2_GRB2, LIG_SH2_STAT5, LIG_SH3_3b, LIG_SUMO_SBM_1b, LIG_WW_Pin1_4, MOD_CK1_1, MOD_CK2_1b, MOD_GSK3_1, MOD_ProDKin_1, TRG_ENDOCYTIC_2b

Q8RDQ9

Fusobacterium outer membrane protein family

FN1449

–

–

CLV_PCSK_SKI1_1, LIG_FHA_1, LIG_FHA_2, LIG_PDZ_Class_2, LIG_SH2_SRCb, LIG_SH2_STAT5, LIG_SUMO_SBM_1b, MOD_GSK3_1, MOD_N-GLC_1b, MOD_PLK

Q8R608

Serine protease

FN1426

Peptidase_S8a, Autotrns_rpta, Autotransportera

Peptidase_S8

CLV_PCSK_SKI1_1, LIG_FHA_2, LIG_PDZ_Class_2, LIG_SH2_STAT5, LIG_SUMO_SBM_1b, MOD_CK1_1, MOD_CK2_1b, MOD_GSK3_1, MOD_PKA_2, TRG_ENDOCYTIC_2b

Q8RFV3

Hypothetical cytosolic protein

FN0579

MG1, A2M_N, A2M_N_2, A2M

A2M_N, A2M_N_2, A2M

LIG_CYCLIN_1b, LIG_FHA_2, LIG_SH2_STAT5, LIG_SUMO_SBM_1b, MOD_CK2_1b, MOD_PIKK_1, MOD_PKA_2

Q8R5P1

DNAse I homologous protein DHP2

FN0891

Exo_endo_phos

Exo_endo_phos

LIG_SH2_GRB2, TRG_ENDOCYTIC_2b

Q8R5Y8

Biotin carboxyl carrier protein of glutaconyl-COA decarboxylase

FN0200

Biotin_lipoyl

Biotin_lipoyl

LIG_SUMO_SBM_1b, LIG_WW_Pin1_4, MOD_ProDKin_1, MOD_SUMOb

Q8R6D6

Serine protease

FN1950

Peptidase_S8a, Autotransportera

Peptidase_S8

LIG_FHA_2, LIG_SH2_STAT5, LIG_SUMO_SBM_1b, MOD_CK1_1, MOD_CK2_1b, MOD_GSK3_1, MOD_PKA_2

Q8RE26

Single-stranded DNA-binding protein

ssb

SSBa

SSB

LIG_BRCT_BRCA1_1, LIG_FHA_1, LIG_FHA_2, LIG_PDZ_Class_2, LIG_SUMO_SBM_1b, MOD_PKA_2, TRG_ENDOCYTIC_2b

Q8REJ1

Dipeptide-binding protein

FN1111

SBP_bac_5

–

CLV_PCSK_SKI1_1, LIG_BRCT_BRCA1_1, LIG_CYCLIN_1b, LIG_SH2_GRB2, LIG_SUMO_SBM_1b, LIG_WW_Pin1_4, MOD_CK2_1b, MOD_ProDKin_1

Q8RG20

Hemin receptor

FN0499

Pluga

–

CLV_PCSK_PC1ET2_1, LIG_CYCLIN_1b, LIG_FHA_1, LIG_MAPK_1, LIG_PDZ_Class_2, LIG_SH2_STAT5, LIG_SH3_3b, LIG_SUMO_SBM_1b, MOD_GSK3_1, MOD_N-GLC_1b

Q8RGC9

Iron(III)-binding protein

FN0375

SBP_bac_8

–

LIG_PP1b, LIG_SH2_GRB2, LIG_SUMO_SBM_1b, LIG_WW_Pin1_4, MOD_CK1_1, MOD_ProDKin_1

Q8RGZ4

Hemolysin activator protein

FN0131

POTRA_2a, ShlBa

–

CLV_PCSK_PC1ET2_1, LIG_SH2_STAT5, LIG_SUMO_SBM_1b, LIG_TRAF2_1b

Q8RH05

Chaperone protein DnaK

dnaK

HSP70

HSP70

CLV_PCSK_PC1ET2_1, CLV_PCSK_SKI1_1, LIG_BRCT_BRCA1_1, LIG_EVH1_1, LIG_FHA_2, LIG_SH2_STAT5, LIG_SH3_3b, LIG_SUMO_SBM_1b, LIG_WW_Pin1_4, MOD_CK1_1, MOD_CK2_1b, MOD_GSK3_1, MOD_PIKK_1, MOD_PLK, MOD_ProDKin_1, TRG_ENDOCYTIC_2b, TRG_LysEnd_APsAcLL_1b

Q8RHM4

Tetratricopeptide repeat protein

FN1990

DnaJ

DnaJ

–

Q8RHU4

Hypothetical lipoprotein

FN1899

DUF3798

–

CLV_C14_Caspase3–7, LIG_FHA_1, LIG_FHA_2, LIG_SH2_STAT5, LIG_SUMO_SBM_1b, LIG_WW_Pin1_4, MOD_CK2_1b, MOD_GSK3_1, MOD_PIKK_1, MOD_PLK, MOD_ProDKin_1

Q8RI19

Hemolysin

FN1817

Fil_haemagg_2a

–

LIG_CYCLIN_1b, LIG_FHA_1, LIG_FHA_2, LIG_SH2_STAT5, LIG_SUMO_SBM_1b, LIG_WW_Pin1_4, MOD_CK1_1, MOD_CK2_1b, MOD_GSK3_1, MOD_N-GLC_1b, MOD_PIKK_1, MOD_PLK, MOD_ProDKin_1, TRG_ENDOCYTIC_2b

Q8RI47

Tetratricopeptide repeat family protein

FN1787

TPR_11a, TPR_1

TPR_11, TPR_1

–

Q8RIF8

50S ribosomal protein L2

rplB

Ribosomal_L2, Ribosomal_L2_C

Ribosomal_L2, Ribosomal_L2_C

CLV_PCSK_SKI1_1, LIG_BIR_II_1, LIG_PP1b, LIG_SH3_3b, LIG_SUMO_SBM_1b, LIG_USP7_1b, LIG_WW_Pin1_4, MOD_PLK, MOD_ProDKin_1, TRG_ENDOCYTIC_2b

Q8RII5

Competence protein

FN1611

HHH_3

–

LIG_TRAF2_1b, MOD_CK2_1 b

Q8RIK0

Hypothetical lipoprotein

FN1590

DUF3798

–

CLV_C14_Caspase3–7, LIG_FHA_1, LIG_FHA_2, LIG_SH2_STAT5, LIG_SUMO_SBM_1b, LIG_WW_Pin1_4, MOD_CK2_1b, MOD_GSK3_1, MOD_PIKK_1, MOD_PLK, MOD_ProDKin_1, TRG_ENDOCYTIC_2b

  1. For every protein, the detected Pfam domains are reported along with the list of domains and SLiMs for which at least one interaction has been inferred
  2. aPfam entry detected in at least one protein sequence stored in the database of known bacterial virulence factors
  3. bMotif for which it was experimentally identified at least one instance in a viral or bacterial protein