Fig. 5

Comparison to published gut transcriptome dataset identifies shared DEGs under microbial regulation. a Venn diagrams highlighting 55 DEGs shared between skin and gut that are regulated by the microbiota. Gut transcriptome data was downloaded from a previously published study [23]. The center square identifies the total number of shared DEGs between the skin (x-axis) and gut (y-axis) datasets in each colonization category. The Venn diagrams highlight DEGs upregulated in the presence (blue, top) and absence (magenta, bottom) of microbiota, respectively, and whether these genes were differentially regulated in the gut in response to microbial colonization (M), colonization of antibiotic resistant microbes (ABresM), or direct effects of antibiotics on host tissue (ABx) or any combination of the above. b Heatmap showing log2 fold change of the 55 DEGs shared between the gut and skin datasets, with parenthesis next to gene names indicating whether these genes were differentially regulated in the gut in response to microbial colonization (M), colonization of antibiotic resistant microbes (ABresM), direct effects of antibiotics on host tissue (ABx), or any combination of the above