Table 2 Gut scoring matrix (maximum 29)
Feature | Score | Description |
|---|---|---|
Colon | ||
Crypt architecture | 0 | Normal |
1 | Irregular | |
2 | Moderate crypt loss (10–50%) | |
3 | Severe crypt loss (50–90%) | |
4 | Small/medium ulcers (< 10 crypt widths) | |
5 | Large ulcers (> 10 crypt widths) | |
Crypt abscesses | 0 | None |
1 | 1–5 | |
2 | 6–10 | |
3 | > 10 | |
Crypt length (medial colon) | 0 | < 250 μm |
1 | 250–300 μm | |
2 | 300–350 μm | |
3 | 350–400 μm | |
4 | > 400 μm | |
Tissue damage | 0 | No damage |
1 | Discrete lesions | |
2 | Mucosal erosions | |
3 | Extensive mucosal damage | |
Inflammatory cell infiltration | 0 | Occasional infiltration |
1 | Increasing leukocytes in lamina propria | |
2 | Confluence of leukocytes extending to submucosa | |
3 | Transmural extension of inflammatory infiltrates | |
Lamina propria neutrophils (PMN) | 0 | 0–5 PMNs/HPF |
1 | 6–10 PMNs/HPF | |
2 | 11–20 PMNs/HPF | |
3 | > 20 PMNs/HPF | |
Ileum | ||
Inflammatory cell infiltration | 0 | Occasional infiltration |
1 | Increasing leukocytes in lamina propria | |
2 | Confluence of leukocytes extending to submucosa | |
3 | Transmural extension of inflammatory infiltrates | |
Lamina propria neutrophils (PMN) | 0 | 0–5 PMNs/HPF |
1 | 6–10 PMNs/HPF | |
2 | 11–20 PMNs/HPF | |
3 | > 20 PMNs/HPF | |
Paneth cell | 0 | Normal: small, densely packed granules |
1 | Irregular: less granules | |
2 | Abnormal: less granules, large vacuolar spaces | |