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Table 3 ARGs and ARG families found in five or more of the communities

From: A reservoir of ‘historical’ antibiotic resistance genes in remote pristine Antarctic soils

ARG description

No. of sites with ARG

 Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system

9

 MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15-membered lactones

8

 dfrE is a chromosome-encoded dihydrofolate reductase found in Enterococcus faecalis

8

 Efflux pump/potassium antiporter system. RosA: major facilitator superfamily transporter

7

 Alanyl-tRNA synthetase conferring resistance to novobiocin in Escherichia coli

7

 The enzymatic inactivation of rifampin by phosphorylation at the 21-OH position

6

 Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate

5

ARG family description

Number of sampled sites

 Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate

12

 ABC efflux/transporter system

12

 Efflux pump/potassium antiporter system. RosA: major facilitator superfamily transporter

9

 dfrE is a chromosome-encoded dihydrofolate reductase found in Enterococcus faecalis

8

 Aminocoumarin resistant alaS. Alanyl-tRNA synthetase conferring resistance to novobiocin in Escherichia coli

7

 Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump

6

 The enzymatic inactivation of rifampin by phosphorylation at the 21-OH position

6

 Aminoglycoside acetyltransferase/nucleotidylyltransferase, which modifies aminoglycosides by acetylation/adenylylation

6

 Major facilitator superfamily transporter, tetracycline efflux pump

5