From: Increased richness and diversity of the vaginal microbiota and spontaneous preterm birth
Characteristics | Term pregnancies (n = 170) | Preterm pregnancies (n = 46) | p value |
---|---|---|---|
Age (mean ± SD, range)1 | 33.6 ± 4.2 (21–45) | 33.65 ± 4.1 (25–45) | 0.948 |
 21–25 | 5 (2.9%) | 1 (2.1%) |  |
 26–35 | 114 (67.1%) | 32 (69.5%) | |
 36–45 | 51 (30.0%) | 13 (28.2%) | |
BMI (mean ± SD, range)1 | 22.9 ± 3.8 (17–40) | 24.2 ± 5.6 (19–43) | 0.125 |
 Underweight (< 18.50) | 7 (4.1%) | 0 (0%) |  |
 Normal weight (18.51–24.9) | 131 (77.0%) | 33 (73.3%) | |
 Overweight (25.0–29.9) | 25 (14.7%) | 8 (17.7%) | |
 Obese (> 30) | 7 (4.1%) | 4 (9.0%) | |
 MD3 | 0 (0%) | 1 (2.2%) | |
Ethnicity2 | 0.261 | ||
 White | 108 (63.5%) | 22 (47.8%) |  |
 East Asian | 26 (15.3%) | 6 (13.0%) | |
 South/Southeast Asian | 15 (8.8%) | 4 (8.7%) | |
 Latin America/Hispanic | 8 (4.7%) | 3 (6.5%) | |
 Black | 3 (1.8%) | 2 (4.4%) | |
 Other/mixed ethnicity | 10 (5.9%) | 6 (13.0%) | |
 MD | 0 (0%) | 3 (6.5%) | |
Community state type (CST)2 | 0.361 | ||
 I | 56 (32.9%) | 17 (37%) |  |
 II | 9 (5.3%) | 5 (10.9%) | |
 III | 28 (16.5%) | 8 (17.4%) | |
 IVA | 31 (18.2%) | 6 (13%) | |
 IVC | 19 (11.2%) | 2 (4.3%) | |
 IVD | 11 (6.5%) | 1 (2.2%) | |
 V | 16 (9.4%) | 7 (15.2%) | |
Estimated bacterial load (log copies of 16S rRNA gene)/swab (mean ± SD, range)1 | 7.78 ± 0.93 (4.89–10.67) | 8.07 ± 0.71 (6.32–10.33) | 0.049 |
Presence of Mollicutes2 | 68 (40%) | 28 (60.8%) | 0.012 |
Presence of Ureaplasma2 | 40 (23.4%) | 14 (30.4%) | 0.337 |
 U. parvum | 37 (21.7%) | 14 (30.4%) |  |
 U. urealyticum | 3 (1.7%) | 0 (0%) | |
Shannon diversity (mean ± SD, range)1 | 1.28 ± 0.86 (0.13–4.52) | 1.81 ± 1.13 (0.34–5.16) | 0.004 |
Chao1 richness (mean ± SD, range)1 | 36.22 ± 14.80 (14.39–115.74) | 46.38 ± 24.19 (20.20–126.01) | 0.009 |