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Fig. 6 | Microbiome

Fig. 6

From: Metatranscriptomic and comparative genomic insights into resuscitation mechanisms during enrichment culturing

Fig. 6

Comparative genomics analysis of correlations between Marinilabiliales microbes and the microorganisms enriched during enrichment culturing. Overview of biotin biosynthesis and precursor salvage. Biosynthetic enzymes: BioH, pimeloyl-[acyl-carrier protein] methyl ester esterase; BioC, malonyl-CoA O-methyltransferase; BioF, 8-amino-7-oxononanoate synthase; BioA, adenosylmethionine-8-amino-7-oxononanoate aminotransferase; BioD, dethiobiotin synthetase; BioB, biotin synthase; and BirA, biotin-[acetyl-CoA-carboxylase] ligase. Biotin translocases include the BioYM ECF-type transporter. The auxotrophic groups, which mainly contain Marinilabiliales bacteria, are unable to synthesize biotin de novo and are missing most of the related pathway genes. Phototrophic groups, which mainly contain Vibrionaceae, Clostridiaceae, Desulfobulbaceae, Desulfovibrionaceae, and Desulfobacteraceae bacteria, can synthesize biotin de novo. The Desulfobacteraceae node has no correlations with the Prolixibacteraceae node and the Marinilabiliaceae node; however, the bacteria within this family were highly enriched and became the dominant family during enrichment culturing. We also analyzed the genomes of this family’s members. Pie slices indicate the total fragments per kilobase of transcript per million fragments mapped (FPKM) of the corresponding gene in each sediment sample

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