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Fig. 2 | Microbiome

Fig. 2

From: Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice

Fig. 2

Inulin supplementation alters the composition of the gut microbiome and increases SCFA concentrations in the gut and portal blood. a Shannon index. b Chao1 index. c Principal coordinate analysis plot generated using an unweighted UniFrac metric. The two components explained 46.5% of the variance. d Principal coordinate analysis plot generated using a weighted UniFrac metric. The two components explained 73.0% of the variance. e Relative abundances of bacterial genera in the caecal contents. f Bacterial taxa at the genus level enriched in LFC, HFC or HFC+IN mice, generated using ALDEx2 analysis. Microbial taxa with the smallest FDR-corrected p values are shown. g SCFA concentrations in the caecum after 20 weeks of diet ingestion. h SCFA concentrations in the portal blood after 20 weeks of diet ingestion. Each point in a, b, f and g represents an individual mouse (thick bars, means; error bars, SEM). LFC, n = 8; HFC, n = 8; HFC + IN, n = 7. *P < 0.05, **P < 0.01, ***P < 0.001 on ANOVA followed by post hoc Tukey’s test (a, b, g and h)

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