Bacterial biogeography of adult airways in atopic asthma

Microbiome

Table 2 Significant associations between the relative abundance of prevalent bacteria genera (present at ≥3% in either of the samples) and clinical and inflammatory parameters in AAs

Variables	rho^§	p value	BH p value^&
Relative abundance of Actinomyces in BB
Serum IgE (IU/mL)	− 0.57	0.014	0.191
BAL neutrophils (%)	− 0.63	0.007	0.182
Relative abundance of Actinomyces in OW
Serum IgE (IU/mL)	− 0.64	0.005	0.082
BAL GM-CSF	− 0.63	0.006	0.082
Relative abundance of Alloiococcus in NB
PC₂₀	0.62	0.006	0.164
Relative abundance of Corynebacterium in NB
Blood eosinophils (cells/mL)	− 0.49	0.041	0.183
BAL eosinophils (%)	− 0.51	0.036	0.183
BAL IL-6	− 0.61	0.009	0.154
BAL IL-7	− 0.54	0.021	0.154
BAL IL-21	− 0.56	0.016	0.154
BAL MIP1-a	− 0.47	0.048	0.187
Relative abundance of Moraxella in NB
Blood eosinophils (absolute)	0.55	0.017	0.152
Sputum eosinophils (%)	0.64	0.007	0.100
BAL eosinophils (%)	0.69	0.002	0.063
BAL ITAC	0.50	0.036	0.188
BAL TNF	0.49	0.042	0.188
Relative abundance of Streptococcus in NB
Blood eosinophils (cells/mL)	0.55	0.017	0.198
BAL IL-7	0.53	0.022	0.198

^§Analysis performed using Spearman correlation coefficient. ^&p values were FDR corrected for multiple comparisons using Benjamini Hochberg method, with values ≤ 0.2 considered significant

ISSN: 2049-2618