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Table 3 Prevalence of genus group present over serial sample collection timepoints in the total bariatric cohort and according to menopausal status, diabetes status and insulin resistance status

From: The association between obesity and weight loss after bariatric surgery on the vaginal microbiota

 

Lactobacillus dominant

n/N (%)

Gardnerella dominant

n/N (%)

High diversity

n/N (%)

Total

n/N (%)

Total bariatric surgery cohort

 Baseline (day of surgery) (n=27)

10/27 (37.0)

5/27 (18.6)

12/27 (44.4)

27/27 (100)

 3 months post-surgery (n=22)

7/22 (31.8)

6/22 (27.3)

9/22 (40.9)

22/22 (100)

 6 months post-surgery (n=19)

10/19 (52.6)

2/19 (10.5)

7/19 (36.9)

19/19 (100)

 Total (n=84)

31/84 (36.9)

16/84 (19.1)

37/84 (44.0)

84/84 (100)

 p valuea

   

0.506

Pre-menopausal women only

 Baseline (day of surgery) (n=17)

6/17 (35.3)

4/17 (23.5)

7/17 (41.2)

17/17 (100)

 3 months post-surgery (n=15)

5/15 (33.3)

4/15 (26.7)

6/15 (40.0)

15/15 (100)

 6 months post-surgery (n=14)

8/14 (57.1)

2/14 (14.3)

4/14 (28.6)

14/14 (100)

 Total (n=58)

22/58 (37.9)

12/58 (20.7)

24/58 (41.4)

58/58 (100)

 p value

   

0.572

Post-menopausal women only

 Baseline (day of surgery) (n=10)

4/10 (40.0)

1/10 (10.0)

5/10 (50.0)

10/10 (100)

 3 months post-surgery (n=7)

2/7 (28.6)

2/7 (28.6)

3/7 (42.8)

7/7 (100)

 6 months post-surgery (n=5)

2/5 (40.0)

0/5 (0)

3/5 (60.0)

5/5 (100)

 Total (n=26)

9/26 (34.6)

4/26 (15.4)

13/26 (50.0)

26/26 (100)

 p value

   

0.999

Non-diabetic women only

 Baseline (day of surgery) (n=19)

6/19 (31.6)

3/19 (15.8)

10/19 (52.6)

19/19 (100)

 3 months post-surgery (n=16)

6/16 (37.5)

4/16 (25.0)

6/16 (37.5)

16/16 (100)

 6 months post-surgery (n=14)

8/14 (57.1)

1/14 (7.2)

5/14 (35.7)

14/14 (100)

 Total (n= 58)

21/58 (36.2)

9/58 (15.5)

28/58 (48.3)

58/58 (100)

 p value

   

0.572

Diabetic women only

 Baseline (day of surgery) (n=8)

4/8 (50.0)

2/8 (25.0)

2/8 (25.0)

8/8 (100)

 3 months post-surgery (n=6)

1/6 (16.7)

2/6 (33.3)

3/6 (50.0)

6/6 (100)

 6 months post-surgery (n=5)

2/5 (40.0)

1/5 (20.0)

2/5 (40.0)

5/5 (100)

 Total (n=26)

10/26 (38.5)

7/26 (26.9)

9/26 (34.6)

26/26 (100)

 p value**

   

n/a

Women without insulin resistancec

 Baseline (day of surgery) (n=4)

1/4 (25.0)

1/4 (25.0)

2/4 (50.0)

4/4 (100)

 3 months post-surgery (n=2)

0/2 (0)

0/2 (0)

2/2 (100)

2/2 (100)

 6 months post-surgery (n=7)

4/7 (57.1)

1/7 (14.3)

2/7 (28.6)

7/7 (100)

 Total (n=13)

5/13 (38.5)

2/13 (15.4)

6/13 (46.1)

13/13 (100)

 p value

   

n/a

Women with insulin resistance

 Baseline (day of surgery) (n=5)

2/5 (40.0)

1/5 (20.0)

2/5 (40.0)

5/5 (100)

 3 months post-surgery (n=1)

0/1 (0)

0/1 (0)

1/1 (100)

1/1 (100)

 6 months post-surgery (n=1)

1/1 (100)

0/1 (0)

0/1 (0)

1/1 (100)

 Total (n=7)

3/7 (42.9)

1/7 (14.3)

3/7 (42.9)

7/7 (100)

 p valueb

   

n/a

  1. aA p value of less than 0.05 demonstrates a significant difference between the proportion (%) of genus group present (Lactobacillus-dominant, Gardnerella-dominant or high diversity VMB) over serial timepoints 0 to 6 months (McNemar’s Chi-square test)
  2. bSample size too small to compute p value using McNemar’s Chi-square test
  3. cWhere concomitant fasting serum samples were available, fasting glucose and fasting insulin levels were identified. Using these values, we were able to calculate the HOMA-IR, according to the following formula: the product of fasting insulin (μU/L) multiplied by fasting glucose (nmol/L) divided by 22.5. The 2nd tertile was used as the cut-off to determine insulin resistance status. Insulin resistance cut-off value: 2.98