Fig. 1From: Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiomeAssociation of serum ferritin with liver fat accumulation, gene richness and the gut microbiome composition. Association of serum ferritin with degree of liver fat accumulation in a the discovery and b replication cohorts (Mann-Kendall trend test and Wilcoxon tests). c Association of hs-CRP with serum ferritin quartiles in the replication cohort (Mann-Kendall trend test and Wilcoxon tests). d Association of microbial gene richness with ferritin quartiles in a subsample of obese women from the discovery and replication cohorts (generalized linear model GLM). e Bacterial families and f genera associated with serum ferritin in a subsample of obese women from the discovery and replication cohorts. Mnet penalized regression models were built on bacterial data including age, BMI, country and hs-CRP as covariates. g Volcano plot of differential bacterial abundance and h metagenome KEGG functions associated with ferritin as calculated from shotgun metagenomic sequencing in an independent cohort of obese and non-obese subjects, adjusting for age, BMI, sex and hs-CRP. Significantly different taxa are coloured according to phylum. adaB, methylated-DNA-[protein]-cysteine S-methyltransferase; cpg; glutamate carboxypeptidase; cycA; d-serine/d-alanine/glycine transporter; fabA, 3-hydroxyacyl-[acyl-carrier protein] dehydratase/trans-2-decenoyl-[acyl-carrier protein] isomerase; fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase; gshA, glutamate-cysteine ligase; nei endonuclease VIII; entF, enterobactin synthetase component F; FTR, FTH1, efeU, high-affinity iron transporter; hemG; menaquinone-dependent protoporphyrinogen oxidase; hutM, histidine permease; mtsC; iron/zinc/manganese/copper transport system permease protein; mtsA; iron/zinc/manganese/copper transport system substrate-binding protein; PARP, poly [ADP-ribose] polymerase; seqA; negative modulator of initiation of replication; yqjH, ferric-chelate reductase (NADPH)Back to article page