Fig. 6
From: Maternal microbiota communicates with the fetus through microbiota-derived extracellular vesicles
Fecal extracellular vesicles (EVs) of pregnant women show accumulation to fetus in pregnant mice. Labeled EVs isolated from the feces of pregnant women were injected intravenously into the mice at the end of the first stage of pregnancy. The animals were sacrificed 24 h after injection, and images of various organs and fetuses were obtained. Fluorescent intensity was assessed in various maternal organs and fetuses. The data are shown as means, with standard deviation shown by the error bar, n = 4 mice, nonsignificant (ns) between organs/fetuses in the Kruskal–Wallis nonparametric test (A). Representative fluorescence image of the organs and fetuses indicated, with regions of interest (ROI) of similar size are drawn in (B)