Fig. 5

Clec7a deficiency blocks the effect of gut fungus on lipid accumulation. A–C Body weight (A), the relative weight of adipose tissues (B), and serum TC and TG (C) of fluconazole (FLU)-treated Clec7a KO mice. C57BL/6 Clec7a KO mice (15 weeks old, male) were fed HFD and treated with or without fluconazole (FLU) for 12 weeks (n = 5). D–F Body weight (D), the relative weight adipose tissues (E), and serum TC and TG (F) in fungus-treated Clec7a KO mice. HFD-fed Clec7a KO mice (31.1 ± 0.1 g) were orally administrated with fungus Ascomycota_sp. (Asco) and Microascaceae_sp. (Micro) for 12 weeks (n = 6–8). G Twenty-nine differentiated genes between Clec7a KO and wild mice by transcriptome analysis (n = 7). H KEGG pathway analysis of the 29 differentiated genes. Differences among the groups were compared using Student’s t-test. *p < 0.05; **p < 0.01; ***p < 0.001; ns p > 0.05