Table 2 The baseline characteristics of each group

Age (years)

19.32 ± 1.52

19.64 ± 1.64

20.47 ± 1.52

20.17 ± 1.23

21.45 ± 1.96

19.87 ± 1.58

BMI (kg/m²)

21.95 ± 2.69

21.89 ± 2.12

21.88 ± 2.36

21.91 ± 2.70

22.56 ± 2.46

21.95 ± 2.05

ns

ns

ns

ns

ns

Liver function

 TP (g/L)

71.67 ± 3.46

72.75 ± 2.93

74.11 ± 4.23

80 ± 6.32

69.65 ± 4.27

74.92 ± 8.6

ns

ns

***

***

*

 BILT (μmol/L)

14.40 ± 5.40

7.81 ± 3.64

17.14 ± 5.94

17.2 ± 7.4

15.07 ± 6.02

14.42 ± 6.2

***

***

***

ns

***

 ALB (g/L)

47.82 ± 2.17

48.52 ± 2.12

49.25 ± 2.8

52.67 ± 4.74

45.77 ± 2.2

48.47 ± 3.58

ns

ns

***

***

ns

 ALT (U/L)

19.63 ± 12.96

18.84 ± 9.07

13.92 ± 5.86

21.87 ± 11.03

26.85 ± 16.84

26.04 ± 19.32

ns

**

ns

ns

**

 AST (U/L)

23.18 ± 7.18

20.65 ± 8.55

16.5 ± 2.54

25.51 ± 6.64

22.82 ± 6.09

23.19 ± 6.48

*

**

***

**

***

 GGT (U/L)

15.87 ± 7.73

14.76 ± 5.61

15.38 ± 4.45

15.51 ± 5.79

20.22 ± 22.23

23.5 ± 15.06

ns

ns

ns

ns

***

 CHE (U/L)

7416 ± 1893

7719 ± 996

7825 ± 1045

8140 ± 1552

8445 ± 1110

7179 ± 1753

ns

ns

ns

ns

ns

 LIPC (U/L)

20.06 ± 6.68

18.59 ± 4.98

14.44 ± 4.88

28.36 ± 11.18

28.21 ± 12.24

25.7 ± 9.07

ns

**

***

ns

***

Kidney function

 UREA (mmol/L)

5.01 ± 1.03

4.62 ± 0.76

5.09 ± 1.04

5.84 ± 1.58

5.99 ± 1.25

5.23 ± 1.14

ns

ns

***

ns

**

 CREA (μmol/L)

78.37 ± 8.85

86.79 ± 9.89

85.95 ± 10.13

86.68 ± 11.78

74.19 ± 7.7

76.25 ± 11.01

***

ns

ns

***

***

 UA (μmol/L)

402.60 ± 74.11

465.95 ± 85.20

385.46 ± 57.03

402 ± 65.79

408.13 ± 78.11

339.96 ± 57.61

***

***

**

ns

***

Glucose metabolism

 GLU (mmol/L)

5.25 ± 0.34

5.09 ± 0.37

3.66 ± 0.45

4.4 ± 0.61

5.06 ± 0.38

4.53 ± 0.45

*

***

***

***

***

Blood lipid

 TG (ng/mL)

8.46 ± 6.26

9.60 ± 6.52

11.67 ± 7.82

9.99 ± 7.59

10.51 ± 7.72

9.66 ± 7.47

ns

ns

ns

ns

ns

 TRIGL (mmol/L)

0.95 ± 0.25

0.82 ± 0.32

0.96 ± 0.27

0.94 ± 0.31

1.05 ± 0.4

0.89 ± 0.35

**

*

*

ns

ns

 HDL (mmol/L)

1.14 ± 0.20

1.17 ± 0.22

1.33 ± 0.22

1.35 ± 0.28

1.24 ± 0.27

1.26 ± 0.5

ns

*

**

*

ns

 CHO (mmol/L)

3.36 ± 0.61

3.24 ± 0.58

3.69 ± 0.56

3.55 ± 0.69

3.59 ± 0.57

3.29 ± 0.63

ns

**

*

ns

ns

 LDL (mmol/L)

1.98 ± 0.55

1.94 ± 0.55

2.06 ± 0.58

1.86 ± 0.58

1.97 ± 0.46

1.82 ± 0.54

ns

ns

ns

ns

ns

 APOA (g/L)

1.20 ± 0.32

1.13 ± 0.13

1.36 ± 0.15

1.34 ± 0.24

1.3 ± 0.19

1.2 ± 0.18

ns

***

***

ns

ns

 APOB (g/L)

0.62 ± 0.14

0.61 ± 0.15

0.65 ± 0.16

0.74 ± 0.18

0.64 ± 0.14

0.62 ± 0.16

ns

ns

**

**

ns

Myocardial enzyme

 CK (U/L)

291.6 ± 254.75

245.58 ± 203.03

131.61 ± 40.68

191.77 ± 97.29

216.47 ± 194.07

160.47 ± 63.23

ns

***

ns

ns

*

 CKMB (U/L)

17.53 ± 5.44

14.23 ± 4.66

12.65 ± 3.07

17.85 ± 5.75

18.81 ± 7.69

16.35 ± 5.41

***

ns

***

ns

**

 LDIP (U/L)

245.57 ± 81.34

191.32 ± 35.52

173.7 ± 31.46

288.23 ± 117.04

209.64 ± 79.82

224.64 ± 70.66

***

ns

***

***

***

Blood ion

 NH3 (μmol/L)

74.26 ± 24.57

63.16 ± 9.15

84.88 ± 34.55

73.18 ± 31.51

68.8 ± 18.03

64.74 ± 29.63

ns

***

ns

ns

ns

 PHO (mmol/L)

1.17 ± 0.12

1.26 ± 0.15

0.99 ± 0.14

1.2 ± 0.17

1.11 ± 0.12

1.12 ± 0.17

**

***

*

*

***

Specific protein

 C3C (g/L)

1.06 ± 0.13

1.01 ± 0.12

1.1 ± 0.16

1.03 ± 0.16

1.05 ± 0.15

1.1 ± 0.17

*

ns

ns

ns

ns

 CRPHS (mg/L)

0.77 ± 0.97

1.24 ± 1.20

0.44 ± 0.4

0.62 ± 1.58

0.79 ± 0.99

1.14 ± 1.67

**

***

***

***

ns

 ProBNP (pg/mL)

19.672 ± 16.02

23.49 ± 14.98

39.97 ± 31.44

13.99 ± 11.05

19.85 ± 15.22

20.39 ± 17.16

ns

*

**

*

ns

Amylase

 AMY-L (U/L)

53.99 ± 17.67

48.89 ± 16.29

58.08 ± 18.8

67.74 ± 19.33

63.65 ± 20.77

68.25 ± 17.7

ns

*

***

ns

***

 AMY-P (U/L)

22.16 ± 7.27

19.81 ± 5.37

21.36 ± 5.86

26.42 ± 6.43

26.03 ± 8.24

28.68 ± 6.26

ns

ns

***

ns

***

Tumor marker

 AFP (g/L)

1.91 ± 0.95

1.81 ± 0.78

1.63 ± 0.64

1.91 ± 0.76

2.68 ± 1.25

1.7 ± 1.19

ns

ns

ns

***

ns

 CEA (ng/mL)

21.5 ± 1.19

2.12 ± 1.19

2.29 ± 1.28

2.51 ± 1.1

2.31 ± 1.23

2.31 ± 0.99

ns

ns

ns

ns

ns

 CA125 (U/mL)

10.37 ± 4.24

4.82 ± 9.87

8.89 ± 3.06

11.12 ± 4.47

9.17 ± 5.66

11.43 ± 10.03

ns

ns

ns

**

ns

 CA153 (U/mL)

8.10 ± 4.02

8.05 ± 3.04

7.91 ± 2.6

12.92 ± 6.09

8.91 ± 3.94

8.86 ± 4.81

ns

ns

***

***

ns

 CA199 (U/mL)

8.61 ± 9.08

6.20 ± 3.26

7.41 ± 4.32

9.7 ± 7.54

9.17 ± 5.66

10.93 ± 7.21

*

ns

*

ns

***

 CA724 (U/mL)

1.37 ± 1.50

3.29 ± 3.64

2.56 ± 2.79

3.64 ± 3.99

2.54 ± 2.77

1.57 ± 1.69

***

ns

ns

*

***

 TPSA (ng/mL)

0.62 ± 0.35

0.57 ± 0.35

0.69 ± 0.44

0.59 ± 0.28

0.65 ± 0.31

0.59 ± 0.56

ns

ns

ns

ns

ns

 FPSA (ng/mL)

0.21 ± 0.11

0.18 ± 0.08

0.25 ± 0.17

0.26 ± 0.13

0.28 ± 0.14

0.2 ± 0.14

ns

*

**

ns

ns

 ProGRP (pg/mL)

33.14 ± 7.09

34.39 ± 6.25

37.33 ± 6.96

36.8 ± 12.07

35.72 ± 9.18

40.91 ± 14.06

ns

ns

ns

ns

**

 CYFRA (ng/mL)

2.29 ± 0.71

2.20 ± 0.70

1.9 ± 0.69

2.29 ± 0.95

2.19 ± 0.94

2.21 ± 0.69

ns

ns

ns

ns

ns

 HE4 (pmol/L)

47.56 ± 8.71

45.40 ± 7.88

46.94 ± 7.23

49.15 ± 8.62

47.5 ± 8.97

56.01 ± 9.71

ns

ns

ns

ns

***

 FERR (ng/mL)

144.76 ± 79.94

128.89 ± 65.55

103.03 ± 52.58

98.41 ± 62.26

321.09 ± 237.15

210.83 ± 199.91

ns

ns

*

***

ns

Thyroid function

 T3 (nmol/L)

1.74 ± 0.25

1.78 ± 0.23

1.85 ± 0.23

1.93 ± 0.3

1.96 ± 0.31

1.92 ± 0.26

ns

ns

**

ns

**

 T4 (nmol/L)

86.03 ± 14.14

86.79 ± 14.30

97.59 ± 16.05

102.49 ± 18.18

90.57 ± 14.89

87.84 ± 15.36

ns

**

***

***

ns

 FT3 (pmol/L)

5.37 ± 0.49

5.13 ± 0.50

5.82 ± 0.7

5.6 ± 0.5

5.75 ± 0.5

5.66 ± 0.58

*

***

***

ns

***

 FT4 (pmol/L)

17.10 ± 2.07

15.11 ± 2.15

18.76 ± 2.35

17.9 ± 2.51

16.9 ± 1.91

16.74 ± 3.67

***

***

***

*

**

 TSH (mIU/L)

2.37 ± 1.38

2.16 ± 1.08

1.73 ± 0.98

2.45 ± 1.36

2.45 ± 1.39

2.69 ± 1.12

ns

ns

ns

ns

**

 A-TG (IU/mL)

10.47 ± 2.86

10.19 ± 0.56

10.18 ± 0.81

11.49 ± 7.59

10.41 ± 2.26

12.09 ± 10.43

ns

ns

ns

ns

ns

 A-TPO (IU/mL)

5.29 ± 0.10

5.60 ± 2.47

5.72 ± 2.68

6.29 ± 3.21

6.85 ± 7.78

5.91 ± 5.06

ns

ns

*

ns

ns

Hormone

 E2 (pmol/L)

174.06 ± 126.98

122.57 ± 35.11

155.47 ± 38.65

154.36 ± 36.43

105.52 ± 71.42

153.24 ± 73.02

***

**

***

**

**

 FSH (IU/L)

4.00 ± 3.11

3.84 ± 1.54

3.29 ± 1.3

4.28 ± 1.81

3.31 ± 1.59

4.8 ± 4.11

ns

ns

ns

**

ns

 LH (mIU/mL)

4.41 ± 1.57

5.32 ± 1.68

5.63 ± 2.01

4.18 ± 1.7

4.6 ± 1.54

5.46 ± 2.35

*

ns

**

ns

ns

 PROG (nmol/L)

1.56 ± 0.38

34.39 ± 6.25

0.96 ± 0.42

0.75 ± 0.28

1.35 ± 0.43

1.15 ± 0.43

***

ns

***

***

ns

 TESTO (nmol/L)

18.52 ± 4.40

18.14 ± 4.29

23.43 ± 5.47

26.05 ± 6.31

20.51 ± 4.41

20.22 ± 7.14

ns

***

***

***

**

 CORT (nmol/L)

446.55 ± 63.61

394.96 ± 89.17

294.49 ± 121.79

368.65 ± 94.53

411.53 ± 110.03

408.72 ± 88.78

**

***

ns

*

ns

 Insulin (pmol/L)

49.95 ± 18.07

39.62 ± 14.14

54.25 ± 20.08

46.89 ± 24.51

48.67 ± 23.29

42.38 ± 29.54

**

**

ns

ns

ns

 CPEPTID (nmol/L)

0.58 ± 0.13

0.55 ± 0.12

0.61 ± 0.16

0.67 ± 0.17

0.57 ± 0.14

0.55 ± 0.21

ns

ns

**

**

ns

 PRL (ng/mL)

17.84 ± 5.83

12.40 ± 3.66

10.72 ± 4.01

8.94 ± 2.86

12.52 ± 5.06

14.32 ± 5.38

***

ns

***

***

ns

Myocardium

 TNT-HS (ng/mL)

0.006 ± 0.002

0.004 ± 0.001

0.006 ± 0.003

0.005 ± 0.002

0.004 ± 0.002

0.005 ± 0.002

***

*

ns

ns

ns

 MYO (ng/mL)

37.84 ± 15.07

28.53 ± 16.79

27.44 ± 4.65

29.06 ± 7.72

32.74 ± 32.79

29.77 ± 6.18

***

*

*

ns

***

Infectious disease

 A-HCV (COI)

0.05 ± 0.03

0.04 ± 0.03

0.05 ± 0.02

0.04 ± 0.01

0.04 ± 0.02

0.05 ± 0.03

**

***

ns

***

**

Bone metabolism

 TP1NP (ng/mL)

154.47 ± 66.14

135.10 ± 76.31

125.71 ± 74.14

125.78 ± 45.4

111.2 ± 38.98

207.16 ± 137.17

ns

ns

ns

ns

***

Septicopyemia

 IL6 (pg/mL)

1.95 ± 0.93

0.55 ± 0.12

3.26 ± 3.1

2.06 ± 1.67

2.27 ± 2.17

2.41 ± 2.0

***

***

***

ns

***

 PCT (ng/mL)

0.03 ± 0.01

0.03 ± 0.01

0.03 ± 0.03

0.03 ± 0.01

0.03 ± 0.02

0.03 ± 0.02

*

ns

**

***

ns

 Rheumatoid arthritis

 A-CCP (U/mL)

7.85 ± 6.33

7.00 ± 0.00

8.28 ± 6.98

9.63 ± 12.06

7.45 ± 3.51

7.5 ± 4.16

ns

ns

ns

ns

ns

Anaphylaxis

 IGE (IU/mL)

158.35 ± 212.99

153.35 ± 217.46

90.79 ± 151.39

211.36 ± 232.39

105.22 ± 135.58

87.46 ± 143.07

ns

ns

ns

*

*