Fig. 8

In-depth exploration of the most informative features selected by our analytical approach. A PCA biplot based on metabolites known to be impacted by peroxisomal dysfunction grouped by treatment (control or NSAID). Ellipses represent 95% CI around the group mean points. Point size indicates quality of representation (cos2) of individuals on the PCA; larger point size reflects higher quality representation. B Fecal concentration (µg/g of feces) of the SCFA butyrate was significantly lower (P = 0.009, independent t-test) in NSAID-treated horses compared with control horses. C Fecal concentration (µg/g of feces) of the SCFA propionate was significantly lower (P = 0.002, independent t-test) in NSAID-treated horses compared with control horses. D Fecal concentration (µg/g of feces) of the SCFA acetate was not significantly different between the groups